LaVine made 16 of 30 shots and had 27 points at halftime. The 6-foot-5 guard also finished with 10 rebounds and eight assists, falling just short of his first career triple-double.
It was LaVine’s second big game against Cleveland in eight days. He scored 42 points on Jan. 20, including 21 in the fourth quarter when the Bulls rallied from a 15-point deficit to win.
Cleveland, which has lost seven straight and 12 of 14, had no better success stopping LaVine this time. He drove past his defender for clear looks at the basket, scored when he was double teamed in the lane, hit five 3-pointers and was 7 of 8 from the line.
LaVine was held to 16 points when the Cavaliers beat the Bulls in Cleveland on Oct. 30. The teams play for the fourth and final time this season in Chicago on March 10.
Tomas Satoransky had 19 points for the Bulls, who were coming off a home loss to Sacramento on Friday and arrived in around 1:30 a.m.
The game was tied at 69 midway through the third quarter before the Bulls went on a 30-7 run to go ahead 99-76. Chicago outscored Cleveland 40-19 in the period.
Cleveland cut a 24-point deficit to 112-103 with two minutes to play, but got no closer. The Cavaliers had lopsided home losses to New York and Washington this week.
Chicago didn’t play like a team that’s been plagued by injuries. Forward Lauri Markkanen, the Bulls’ second-leading scorer, will miss four to six weeks because of an injured right hip. The 7-footer had an MRI on Thursday after experiencing soreness in the hip for about a week.